Peptides vs SARMs analyzed by a scientist

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References

[1] C. Y. BOWERS, F. A. MOMANY, G. A. REYNOLDS, A. HONG, On the in Vitro and in Vivo Activity of a New Synthetic Hexapeptide that Acts on the Pituitary to Specifically Release Growth Hormone, Endocrinology, Volume 114, Issue 5, 1 May 1984, Pages 1537–1545, https://doi.org/10.1210/endo-114-5-1537

[2] Mao Y, Tokudome T, Kishimoto I. The cardiovascular action of hexarelin. J Geriatr Cardiol. 2014 Sep;11(3):253-8. doi: 10.11909/j.issn.1671-5411.2014.03.007. PMID: 25278975; PMCID: PMC4178518.

[3] McDonald, H., J. Peart, N.D. Kurniawan, G. Galloway, S.G. Royce, C.S. Samuel, and C. Chen. "Hexarelin Targets Neuroinflammatory Pathways to Preserve Cardiac Morphology and Function in a Mouse Model of Myocardial Ischemia-Reperfusion." Biomedicine & Pharmacotherapy, vol. 127, 2020, 110165. ISSN: 0753-3322. DOI: 10.1016/j.biopha.2020.110165.

[4] A. Rahim, P. A. O’Neill, S. M. Shalet, Growth Hormone Status during Long-Term Hexarelin Therapy, The Journal of Clinical Endocrinology & Metabolism, Volume 83, Issue 5, 1 May 1998, Pages 1644–1649, https://doi.org/10.1210/jcem.83.5.4812

[5] Avallone R, Demers A, Rodrigue-Way A, Bujold K, Harb D, Anghel S, Wahli W, Marleau S, Ong H, Tremblay A. A growth hormone-releasing peptide that binds scavenger receptor CD36 and ghrelin receptor up-regulates sterol transporters and cholesterol efflux in macrophages through a peroxisome proliferator-activated receptor gamma-dependent pathway. Mol Endocrinol. 2006 Dec;20(12):3165-78. doi: 10.1210/me.2006-0146. Epub 2006 Sep 7. PMID: 16959872.

[6] Rodrigue-Way A, Demers A, Ong H, Tremblay A. A growth hormone-releasing peptide promotes mitochondrial biogenesis and a fat burning-like phenotype through scavenger receptor CD36 in white adipocytes. Endocrinology. 2007 Mar;148(3):1009-18. doi: 10.1210/en.2006-0975. Epub 2006 Nov 30. PMID: 17138655.

[7] Clamp LD, Hume DJ, Lambert EV, Kroff J. Enhanced insulin sensitivity in successful, long-term weight loss maintainers compared with matched controls with no weight loss history. Nutr Diabetes. 2017 Jun 19;7(6):e282. doi: 10.1038/nutd.2017.31. PMID: 28628125; PMCID: PMC5519190.

[8] Hotta M, Ohwada R, Katakami H, Shibasaki T, Hizuka N, Takano K. Plasma levels of intact and degraded ghrelin and their responses to glucose infusion in anorexia nervosa. J Clin Endocrinol Metab. 2004 Nov;89(11):5707-12. doi: 10.1210/jc.2004-0353. PMID: 15531532.

[9] Meanti R, Rizzi L, Bresciani E, Molteni L, Locatelli V, Coco S, Omeljaniuk RJ, Torsello A. Hexarelin Modulation of MAPK and PI3K/Akt Pathways in Neuro-2A Cells Inhibits Hydrogen Peroxide-Induced Apoptotic Toxicity. Pharmaceuticals (Basel). 2021 May 8;14(5):444. doi: 10.3390/ph14050444. PMID: 34066741; PMCID: PMC8150489.

[10] Tavares AB, Micmacher E, Biesek S, Assumpção R, Redorat R, Veloso U, Vaisman M, Farinatti PT, Conceição F. Effects of Growth Hormone Administration on Muscle Strength in Men over 50 Years Old. Int J Endocrinol. 2013;2013:942030. doi: 10.1155/2013/942030. Epub 2013 Dec 8. PMID: 24382963; PMCID: PMC3870652.

[11] Frieboes RM, Antonijevic IA, Held K, Murck H, Pollmächer T, Uhr M, Steiger A. Hexarelin decreases slow-wave sleep and stimulates the secretion of GH, ACTH, cortisol and prolactin during sleep in healthy volunteers. Psychoneuroendocrinology. 2004 Aug;29(7):851-60. doi: 10.1016/S0306-4530(03)00152-5. PMID: 15177700.

[12] Ciccarelli E, Grottoli S, Razzore P, Gianotti L, Arvat E, Deghenghi R, Camanni G, Ghigo E. Hexarelin, a synthetic growth hormone releasing peptide, stimulates prolactin secretion in acromegalic but not in hyperprolactinaemic patients. Clin Endocrinol (Oxf). 1996 Jan;44(1):67-71. doi: 10.1046/j.1365-2265.1996.626446.x. PMID: 8706295.

[13] Massoud AF, Hindmarsh PC, Brook CG. Hexarelin-induced growth hormone, cortisol, and prolactin release: a dose-response study. J Clin Endocrinol Metab. 1996 Dec;81(12):4338-41. doi: 10.1210/jcem.81.12.8954038. PMID: 8954038.

[14] Thapa S, Bhusal K. Hyperprolactinemia. 2023 Jul 24. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. PMID: 30726016.

[15] Kumar P, Kumar N, Thakur DS, Patidar A. Male hypogonadism: Symptoms and treatment. J Adv Pharm Technol Res. 2010 Jul;1(3):297-301. doi: 10.4103/0110-5558.72420. PMID: 22247861; PMCID: PMC3255409.

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